The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
Eligible age
18–99 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11. Since RRP is an orphan disease, it is an understudied disease entity with correspondingly few treatment options. The investigators hypothesize that by understanding the biology of RRP and the failed host immune responses against HPV, novel and rational therapies can be developed. This study will examine the genetic and immunologic alterations found in these rare tumors and distant metastatic involved sites (such as the lung) in patients diagnosed with RRP.
Sponsor: Massachusetts General Hospital
You may qualify if…
- ✓ History of HPV-associated Recurrent Respiratory Papillomatosis
- ✓ Has pulmonary lesions
You may not qualify if…
- ✕ None
Where it's recruiting
New Haven
Source: ClinicalTrials.gov · NCT06412172 · last updated 2025-08-12