Cardiac-Control Affecting Learning Through Mindfulness (CALM)
Eligible age
50–70 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
Sponsor: University of Southern California
You may qualify if…
- ✓ Fluent in English
- ✓ Black/African-American or White/European-American
- ✓ Aged between 50-70 years old
- ✓ Non-pregnant and non-menstruating (for at least the past year)
- ✓ Have normal or corrected-to-normal vision and hearing
- ✓ Have reliable access to wifi
- ✓ Have an email account that you check regularly
- ✓ Have a phone that receives text messages
You may not qualify if…
- ✕ Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea)
- ✕ Have cognitive impairment
- ✕ Have regularly played Lumosity games in the past 6 months
- ✕ Have any conditions listed below that are not safe for MRI
- ✕ \*Metal in any parts of your body
- ✕ Claustrophobia
- ✕ Have worked as a machinist, metal worker, or in any profession or hobby grinding metal?
- ✕ Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body)
Where it's recruiting
Los Angeles
Source: ClinicalTrials.gov · NCT06410157 · last updated 2026-05-13