RecruitingMajor Depressive DisorderObsessive-Compulsive DisorderSchizophrenia
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Eligible age
18–65 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.
Sponsor: Brigham and Women's Hospital
You may qualify if…
- ✓ Age 18-65
- ✓ English proficiency sufficient for informed consent, questionnaires/tasks, and treatment
- ✓ Primary diagnosis of one of the following: major depressive disorder (MDD), obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), or schizophrenia (determined by focal assessment using the Structured Clinical Interview for DSM-5)
- ✓ ≥20 on the Beck Depression Inventory for patients with MDD
- ✓ ≥16 on the Beck Anxiety Inventory for patients with GAD
- ✓ ≥16 on the Yale-Brown Obsessive-Compulsive Scale for patients with OCD
- ✓ ≥58 on the Positive and Negative Symptom Scale for patients with schizophrenia
- ✓ Stable psychotropic medication regimen, or remain medication free, for 4 weeks prior to treatment (Medication changes during study enrollment period will be tracked for post hoc analysis).
You may not qualify if…
- ✕ Active pregnancy as determined by a urine pregnancy test
- ✕ Cluster B personality disorders (antisocial personality disorder, borderline personality disorder, histrionic personality disorder, narcissistic personality disorder)
- ✕ PTSD with active, clinically significant symptoms, as determined by clinician
- ✕ Diagnosis of Schizoaffective Disorder, Bipolar Type
- ✕ Recent (within 4 weeks) or concurrent use of rapid-acting antidepressant agent (ketamine/esketamine/ECT)
- ✕ Ferromagnetic metallic implant that would contraindicate receiving TMS or obtaining MRI
- ✕ Any other TMS or MRI safety concerns identified by the clinician
- ✕ Receiving or planning to receive other TMS treatments during course of participation
Where it's recruiting
California
Sunnyvale
Massachusetts
Boston
Source: ClinicalTrials.gov · NCT06376734 · last updated 2026-02-17