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RecruitingInsomniaDepression

Sleep Mechanisms Of Regulating Emotions

Eligible age

18–65 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

This project is the second phase of a two-phased project investigating the impact of a proven sleep intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I) on engagement of the emotion regulation brain network as a putative mechanistic target.

Sponsor: Stanford University

You may qualify if…

  • ✓ Males and females of any racial or ethnic group, aged 18-65
  • ✓ Subjective complaint of insomnia associated with daytime impairment or distress (ISI ≥ 10)
  • ✓ Insomnia complaint ≥ 3 months in duration
  • ✓ Subjective complaint of depressive symptoms as defined by scores of ≥ 14 on the BDI
  • ✓ Fluent and literate in English
  • ✓ Written, informed consent
  • ✓ Reside within 60 miles of Stanford University

You may not qualify if…

  • ✕ Presence of other sleep or circadian rhythm disorders that significantly contribute to their sleep disturbance. The presence of these disorders will be assessed by the DUKE structured interview for sleep disorders
  • ✕ Use of psychotropic medications that would significantly impact sleep, alertness, or mood and unwilling or unable to discontinue medication specifically prescribed for sleep disturbance \> two weeks (anti-depressants) or \>1 week (sleep medications) prior to baseline data collection
  • ✕ Excessive alcohol consumption (\>14 drinks per week or \> 4 drinks per occasion)
  • ✕ Presence of suicidal ideations representing imminent risk as determined by the empirically-supported, standardized suicide risk assessment
  • ✕ General medical condition, disease or neurological disorder that interferes with the assessments
  • ✕ Substance abuse or dependence
  • ✕ History of significant head trauma followed by persistent neurological deficits or known structural brain abnormalities OR traumatic brain injury in the past two months
  • ✕ Severe impediment to vision, hearing and/or hand movement, likely to interfere with the ability to complete the assessments, or are unable and/or unlikely to follow the study protocols

Where it's recruiting

California

Palo Alto

Source: ClinicalTrials.gov · NCT06373718 · last updated 2026-04-20

Sleep Mechanisms Of Regulating Emotions · TrialPath