RecruitingType2diabetes
Type 2 Diabetes and Blood Brain Barrier Improvement
Eligible age
40–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.
Sponsor: University of California, Los Angeles
You may qualify if…
- ✓ Diagnosed T2DM
- ✓ Outpatient status
- ✓ Able to lay flat for imaging
You may not qualify if…
- ✕ A previous history of stroke
- ✕ Current in-take of thiamine
- ✕ Known thiamine allergy
- ✕ Seizure disorder
- ✕ Head trauma
- ✕ Myocardial infarction
- ✕ Current pregnancy (if female)
- ✕ Diagnosed neuropsychiatric disorders (clinical depression, schizophrenia, manic-depression)
Where it's recruiting
California
Los Angeles
Source: ClinicalTrials.gov · NCT06322212 · last updated 2026-03-13