RecruitingNeoplasms
A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors
Eligible age
18+ yrs
Accepts
All genders
Locations
3 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this study is to determine the safety, feasibility, recommended dose(s) and regimen(s) of JNJ-87704916 as monotherapy and in combination with cetrelimab.
Sponsor: Johnson & Johnson Enterprise Innovation Inc.
You may qualify if…
- ✓ For Part 1: Individuals with a diagnosis of advanced or metastatic solid tumor exhausting all available standard of care therapy; Part 2: Individuals with histologically or cytologically confirmed metastatic or locally advanced NSCLC
- ✓ Have at least 1 injectable tumor
- ✓ Eastern cooperative oncology group (ECOG) performance status of grade 0 or 1
- ✓ A participant who can have children must have a negative pregnancy test before the first dose of study treatment and during the study
- ✓ Thyroid function laboratory values within normal range except for participants on thyroid hormone replacement therapy
You may not qualify if…
- ✕ Active disease involvement of the CNS (example, primary central nervous system tumors, metastases, leptomeningeal disease). Some exceptions are allowed
- ✕ Prior history of, or active, significant herpetic infections (example, herpetic keratitis or encephalitis) or active herpetic infections that require ongoing systemic anti-viral therapy
- ✕ Active infection or condition that requires treatment with systemic anti-infective agents (example, antibiotics, antifungals, or antivirals) within 7 days prior to the first dose of study treatment or chronic use of anti-infective agents
- ✕ History of solid organ or hematologic stem cell transplantation
- ✕ Known positive test result for human immunodeficiency virus (HIV) or other immunodeficiency syndrome
- ✕ History of allergy to protein-based therapies or history of any significant drug allergy (such as anaphylaxis, hepatotoxicity, or immune-mediated thrombocytopenia or anemia)
Where it's recruiting
Source: ClinicalTrials.gov · NCT06311578 · last updated 2026-07-06