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RecruitingOpioid Use DisorderChronic PainAnxiety Disorder

Low-Intensity Focused Ultrasound and the Complex Patient

Eligible age

18–65 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

Studying the effects of Low Intensity Focused Ultrasound (LIFU) on measures of pain, craving, and anxiety in a complex patient population.

Sponsor: Virginia Polytechnic Institute and State University

You may qualify if…

  • ✓ 1. Males and females aged 18-65 years
  • ✓ 2. Current diagnosis of Chronic Back Pain as defined by pain duration of at least three months, with back pain being an ongoing problem for at least half the days of the last six months.
  • ✓ 3. Have evidence of central sensitization (CS) as measured by the Widespread Pain/Symptom Severity Index (WPSSI) with a score of Widespread Pain Index (WPI) ≥ 7 and Symptom Severity (SS) ≥ 5 or WPI = 3-6 and SS ≥ 9.
  • ✓ 4. Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for current opiate use disorder as diagnosed by the Structured Clinical Interview for DSM-5.
  • ✓ 5. Be in treatment for opioid use disorder (OUD) including buprenorphine or methadone.
  • ✓ 6. Meet the DSM-5 criteria for a current anxiety disorder: generalized anxiety disorder, post-traumatic stress disorder or social anxiety disorder as diagnosed by the Structured Clinical Interview for DSM-5.

You may not qualify if…

  • ✕ 1. Evidence of neuropathic pain
  • ✕ 2. Previous spine surgery
  • ✕ 3. Current substance use disorder other than OUD or tobacco use disorder
  • ✕ 4. Current DSM-5 diagnosis of schizophrenia or schizo-affective disorder
  • ✕ 5. Chronic Pain Conditions other than chronic back pain
  • ✕ 6. Daily opiate use other than buprenorphine/methadone for OUD/pain control
  • ✕ 7. Pregnant or breastfeeding
  • ✕ 8. History of head injury, seizures, neurologic disorders including cerebrovascular disease, stroke, brain surgery, brain tumor, multiple sclerosis, or neurodegenerative diseases

Where it's recruiting

Virginia

Roanoke

Source: ClinicalTrials.gov · NCT06297200 · last updated 2025-11-03

Low-Intensity Focused Ultrasound and the Complex Patient · TrialPath