Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
Eligible age
21+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis. Participants (n=32) will complete 7 double-blind, double-dummy outpatient sessions in randomized order. In each session, participants will self-administer placebo (0 mg THC) or active vaporized cannabis (5 or 25 mg THC, via a handheld vaporizer called the Mighty Medic) and a placebo drink (BAC 0.0%) or alcohol drink calculated to produce a breath alcohol concentration (BAC) of 0.05%. Participants will also complete a positive control session in which the participant administers placebo cannabis and alcohol at a target BAC of 0.08% (the legal threshold for driving impairment in most U.S. states).
Sponsor: Johns Hopkins University
You may qualify if…
- ✓ 1. Have provided written informed consent
- ✓ 2. Be at least 21 years of age
- ✓ 3. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests
- ✓ 4. Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at each study visit
- ✓ 5. Have not donated blood in the prior 30 days
- ✓ 6. Report at least 1 day of binge drinking in the past 3 months (greater than 4 or 5 drinks on a single occasion for women and men, respectively)
- ✓ 7. Report at least 1 use of cannabis in the past 3 years
- ✓ 8. Provide negative urine test for illicit drug use (excluding THC) and negative breath alcohol test (0% BAC) at screening and before study sessions
You may not qualify if…
- ✕ 1. Psychoactive drug use (aside from cannabis, nicotine, alcohol, or caffeine) in the past month
- ✕ 2. History of or current evidence of significant medical condition that would put the participant at risk
- ✕ 3. Evidence of current psychiatric condition (MINI for DSM-V)
- ✕ 4. Meet criteria for severe alcohol use disorder (MINI for DSM-V)
- ✕ 5. CIWA-Ar score \> 9
- ✕ 6. Use of cannabis, on average, more than 3 days/week over past 3 months
- ✕ 7. Enrollment in another clinical trial or receiving of any drug as part of research within past 30 days
- ✕ 8. Shipley vocabulary score \<18 (corresponds to 5th grade reading level)
Where it's recruiting
Baltimore
Source: ClinicalTrials.gov · NCT06293040 · last updated 2026-09-08