RecruitingAsthmaAsthma ChronicOverweight and Obesity
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Eligible age
18+ yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
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About this study
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
Sponsor: Johns Hopkins University
You may qualify if…
- ✓ Physician-diagnosed asthma on maintenance therapy
- ✓ Not well-controlled asthma (ACT score \<20, or at least one asthma exacerbation requiring corticosteroids in the prior 12 months)
- ✓ Overweight or obesity: Body mass index ≥25kg/m2
- ✓ Adult: Age ≥18
You may not qualify if…
- ✕ Currently pregnant, expect to become pregnant in the next 6 months or are currently breastfeeding
- ✕ Major cardiovascular disease: heart failure, heart attack or stroke within the last 6 months
- ✕ Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis
- ✕ Active smoking or former smoker with ≥20 pack-year smoking history
- ✕ Chronic kidney disease: estimated glomerular filtration rate ≤60 mL/min/1.73 m2
- ✕ Heavy alcohol use: in a typical week, 8 or more drinks for a woman or 15 or more drinks for a man
- ✕ Liver disease: elevation in aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \> 2x the upper limit of normal or prior diagnosis of liver disease
- ✕ Anemia: hemoglobin \< 13 g/dl in males and hemoglobin \< 11 g/dl in females
Where it's recruiting
Source: ClinicalTrials.gov · NCT06273072 · last updated 2026-01-16