TTrialPathMatch Me to Trials
← Back to trials
RecruitingAdvanced Melanoma

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

Eligible age

12+ yrs

Accepts

All genders

Locations

24 states

Healthy volunteers

No

See if you qualify for this study

Answer a few quick questions about your location and health. Takes about a minute.

Check my eligibility →

About this study

This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage IIIb-IV cutaneous melanoma whose disease progressed on an anti PD-1 and an anti-CTLA-4 containing regimen (administered either as a combination regimen or in sequence) or who are not candidates for treatment with an anti-CTLA-4 therapy.

Sponsor: Replimune, Inc.

Where it's recruiting

Arizona

Gilbert

California

La Jolla · Los Angeles · Orange · Palo Alto …

Colorado

Aurora · Englewood

District of Columbia

Washington D.C.

Florida

Hollywood · Jacksonville · Tampa

Georgia

Atlanta

Illinois

Chicago · Park Ridge

Iowa

Iowa City

Kansas

Westwood

Kentucky

Louisville

Michigan

Detroit · Grand Rapids

Minnesota

Minneapolis

Source: ClinicalTrials.gov · NCT06264180 · last updated 2026-07-15