VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
Eligible age
12+ yrs
Accepts
All genders
Locations
24 states
Healthy volunteers
No
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About this study
This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage IIIb-IV cutaneous melanoma whose disease progressed on an anti PD-1 and an anti-CTLA-4 containing regimen (administered either as a combination regimen or in sequence) or who are not candidates for treatment with an anti-CTLA-4 therapy.
Sponsor: Replimune, Inc.
Where it's recruiting
Gilbert
La Jolla · Los Angeles · Orange · Palo Alto …
Aurora · Englewood
Washington D.C.
Hollywood · Jacksonville · Tampa
Atlanta
Chicago · Park Ridge
Iowa City
Westwood
Louisville
Detroit · Grand Rapids
Minneapolis
Source: ClinicalTrials.gov · NCT06264180 · last updated 2026-07-15