RecruitingDepressionMood DisordersHealthy (Controls)
Cold and Heat Investigation to Lower Levels of Depression
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment followup assessments.
Sponsor: Barry Sandler
You may qualify if…
- ✓ Individuals who currently meet study criteria for depression or individuals who do not currently meet criteria for depression
- ✓ English or Spanish speaking (able to provide informed consent and complete questionnaires in one of these languages)
- ✓ Able and willing to adhere to trial requirements, including attending all trial visits, preparatory and follow-up sessions, and completing all trial evaluations.
You may not qualify if…
- ✕ Previous adverse reaction to hypothermia, hyperthermia and/or infrared exposure
- ✕ Use of any medication that may impact thermoregulatory capacity.
- ✕ Pregnancy, active lactation, or intention to become pregnant during the study period.
- ✕ Endorses current active suicidal ideation with a plan or made a suicide attempt in the prior 6 months.
Where it's recruiting
Colorado
Edwards
Source: ClinicalTrials.gov · NCT06263738 · last updated 2025-11-13