RecruitingEpisodic Migraine
Chiropractic Care for Episodic Migraine
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Migraine, a chronic intermittent headache disorder, ranks in the top five causes of years lived with disability. One promising non-pharmacologic and integrative treatment for migraine may be chiropractic care due to the co-occurrence of migraine and musculoskeletal complaints. The goal of this application is to perform a pilot study of chiropractic care for episodic migraine to help inform the design of a future, full-scale pragmatic effectiveness trial.
Sponsor: Brigham and Women's Hospital
You may qualify if…
- ✓ Age 18-65 years
- ✓ Confirmed diagnosis of migraine with or without aura which does not meet criteria for chronic migraine according to the International Classification for -Headache Disorders (ICHD)-3 guidelines at the screening visit with the study physician
- ✓ History of migraines dating for at least one year
- ✓ Completion of at least 26 headache diary days out of 28
- ✓ Confirmed migraine frequency ≥4 to ≤13 days per month during a run-in period
- ✓ If use of medication is applicable, dose must be stable for 2 months prior to study enrollment
- ✓ If use of medication for non-migraine pain condition is applicable (with the exception of episodic tension type headache), dose must be stable for 2 months prior to study enrollment
- ✓ Willing and able to complete all study procedures and be randomized to either of the two intervention groups
You may not qualify if…
- ✕ Non-Veterans (VAMC only)
- ✕ Received botulinum toxin treatment for headache and/or neck pain within the 4 months prior to the start of the baseline phase
- ✕ Received chiropractic care for any condition within the 3 months prior to the start of the baseline phase
- ✕ Received behavioral interventions (e.g., cognitive behavioral therapy, acceptance and commitment therapy, mindfulness, relaxation techniques, hypnosis) within the past 3 months)
- ✕ Used neuromodulation (i.e., "headache devices"), procedures for migraine prevention within the 2 months before the baseline period, or investigational medications or headache devices for at least 90 days prior to screening
- ✕ Diagnosis of medication overuse headache according to the ICHD-3 guidelines at the screening visit with the study physician
- ✕ Traumatic Brain Injury ≤ 1 year before screening visit or worsening of migraine as noted by the screening study physician
- ✕ Head or neck trauma within the past year causing neurological or musculoskeletal signs or symptoms requiring treatment
Where it's recruiting
Massachusetts
Boston
Source: ClinicalTrials.gov · NCT06229834 · last updated 2025-07-09