RecruitingHeart FailureDiuretic Resistance
Mechanisms of Diuretic Resistance in Heart Failure, Aim 3
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Randomized double-blind placebo-controlled crossover study design
Sponsor: Yale University
You may qualify if…
- ✓ Clinical diagnosis of heart failure
- ✓ No plan for titration/change of heart failure medical or device therapies during the study period.
- ✓ Absence of non-elective hospitalizations in the previous 2 months.
- ✓ At optimal volume status by symptoms, exam, and dry weight.
- ✓ Serum potassium ≤ 5.0 mmol/L
- ✓ Serum sodium ≥ 130 milliequivalents/ liter (mEq/L)
- ✓ Hemoglobin ≥8 g/dL
- ✓ Age \>18 years
You may not qualify if…
- ✕ Glomerular filtration rate (GFR) \<20 ml/min/1.73m2
- ✕ Use of any non-loop type diuretic in the last 7 days with the exclusion of low dose aldosterone antagonist (e.g., spironolactone ≤50 mg)
- ✕ History of flash pulmonary edema or a "brittle" volume sensitive HF phenotype such as amyloid cardiomyopathy
- ✕ Hemoglobin \< 8 g/dL
- ✕ Pregnant or breastfeeding
- ✕ Cirrhosis or known liver disease
- ✕ History of metabolic or respiratory acidosis within 30 days
- ✕ Use of metformin, acetazolamide, or any other agent that could predispose to acidosis
Where it's recruiting
Connecticut
New Haven
Source: ClinicalTrials.gov · NCT06209359 · last updated 2026-05-22