RecruitingObstructive Sleep Apnea
MicroRNAs as Biomarkers for Obstructive Sleep Apnea
Eligible age
18–75 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
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About this study
Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.
Sponsor: University of Pennsylvania
You may qualify if…
- ✓ age 18-75 years
- ✓ moderate-severe OSA (defined as AHI ≥15 events/hour)
- ✓ willing to accept PAP therapy
- ✓ age 18-75 years
- ✓ no OSA (defined as AHI \<5 events/hour)
You may not qualify if…
- ✕ current use of PAP or other OSA treatments
- ✕ home oxygen therapy
- ✕ recent changes (within 3 months) to BP medications among those who are on these medications
- ✕ presence of Cheyne-Stokes Respiration (CSR) in sleep study
- ✕ predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events)
- ✕ pregnancy
- ✕ clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
- ✕ organ transplantation
Where it's recruiting
Ohio
Columbus
Pennsylvania
Philadelphia
Source: ClinicalTrials.gov · NCT06189755 · last updated 2026-08-03