Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
Eligible age
18–70 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.
Sponsor: University of Colorado, Denver
You may qualify if…
- ✓ Generally healthy men and women aged 18-70
- ✓ BMI between 30-40
- ✓ Less than 1 hour of exercise per week
- ✓ Women:
- ✓ 1. may be pre or post menopausal
You may not qualify if…
- ✕ Type 1 or Type 2 diabetes
- ✕ Thyroid disease
- ✕ History of lung disease
- ✕ Active use of nicotine
- ✕ Severe plasma lipid disorders
- ✕ Taking hormone replacement drugs, blood thinners, or thiazoladinediones
- ✕ Women:
- ✕ 1. Currently going through menopause or peri-menopause
Where it's recruiting
Aurora
Source: ClinicalTrials.gov · NCT06129110 · last updated 2026-05-15