Magnetic Brain Stimulation and Computer-based Motor Training for Rehabilitation After Stroke
Eligible age
20–80 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
No
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About this study
The goal of the present clinical trial is to explore whether an innovative technology-based approach can help individuals who have had a stroke and can no longer move their hands with ease. Our approach consists of a combination of two technologies: Transcranial Magnetic Stimulation (TMS) and a Brain-Computer Interface (BCI). The former entails the application of magnetic fields over the head to stimulate the brain preparing it for a better ability to produce movement. The latter consists of measuring brain activity to personalize a type of computer-based training that is designed to increase communication between the brain and the muscles.
Sponsor: Max Planck Institute for Human Cognitive and Brain Sciences
You may qualify if…
- ✓ 1. Diagnosis of a subcortical stroke at least 6 months before the initiation of the trial and confirmed with magnetic resonance imaging (MRI) or computed tomography
- ✓ 2. Present moderate to severe hemiparesis in an upper limb
- ✓ 3. Language comprehension as well as visual and auditory perception sufficient to engage in Brain Computer Interface training
- ✓ 4. Age from 20 to 80 years old
- ✓ 5. Clear consciousness and stable vital signs
- ✓ 6. Eligible for MRI, EEG, BCI and TMS methods
You may not qualify if…
- ✕ 1. Drug abuse or recent changes in medications that may alter the central nervous system when the measurements begin or during the measurements (e.g., benzodiazepines, serotoninergic and dopaminergic agents)
- ✕ 2. History of seizure
- ✕ 3. Bone, joint and muscle diseases
- ✕ 4. Peripheral neuropathy or other neurological or psychiatric diseases (including, tinnitus, migraine, or mood disorders with the exception of minimal, mild, and moderate depression, reflected as a Beck depression scale score lower than 29).
- ✕ 5. Strong cognitive deficits (including speech, attention, hearing, vision, sensation or intelligence deficits) reflected as a Montreal Cognitive Assessment (MoCA) score lower or equal to 24
- ✕ 6. Lesions in the upper extremities
- ✕ 7. Bone, joint and muscle diseases
- ✕ 8. Severe spasticity (higher than 3) or pain in the upper limb and affecting wrist extension
Source: ClinicalTrials.gov · NCT06116942 · last updated 2023-11-09