RecruitingSuicideSuicidal IdeationDepression
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
Sponsor: Lindsay Maguire, MD
You may qualify if…
- ✓ Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
- ✓ Require inpatient stabilization for SI or actions based on clinical observation and interview
- ✓ Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus
- ✓ Have a Glasgow Coma Score (GCS) of 15
- ✓ Age 18-65
You may not qualify if…
- ✕ Current or past history of psychosis
- ✕ Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater
- ✕ History of ketamine use disorder
- ✕ History of liver transplant
- ✕ Pregnancy or breastfeeding
- ✕ Imprisonment or inability to consent
- ✕ Positive urine drug screen or serum alcohol level
- ✕ Hypertension (SBP \> 160 or DBP \> 100 before administration of ketamine)
Where it's recruiting
Kansas
Kansas City
Source: ClinicalTrials.gov · NCT06085937 · last updated 2026-04-15