Patients Derived Organoids in Ovarian Cancer
Eligible age
18–80 yrs
Accepts
Women
Locations
0 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
Among cancer models, patients derived organoids (PDOs) best reproduce tumor's tissue architecture, intratumor heterogeneity and are able to mimic in vivo patients' drugs response. For these reasons, it has been designed a study to assess the feasibility of PDOs immune cells co-culture in OC patients and the concordance between ex vivo sensitivity and in vivo treatment response. If proven effective and reliable, PDOs could be introduced into clinical practice as empirical predictor of patients' response to antineoplastic drugs.
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
You may qualify if…
- ✓ 1. Preoperative clinical, serological and radiologic suspicion of International Federation of Gynecology and Obstetrics (FIGO) stage IIIC or greater ovarian, fallopian tube, or primary peritoneal cancer;
- ✓ 2. Histologic diagnoses of epithelial ovarian cancer at frozen section
- ✓ 3. Age \>18 and years;
- ✓ 4. Estimated life expectancy of at least 4 weeks;
- ✓ 5. Performance status (PS) according to Eastern Cooperative Oncology Group (ECOG) \< 2
You may not qualify if…
- ✕ 1. Non-serous histology at frozen section;
- ✕ 2. Patients with a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (\> 10 mg equivalent prednisone/daily) or any other form of immunosuppressive therapy within 7 days prior to the enrollment.
Source: ClinicalTrials.gov · NCT06085404 · last updated 2025-03-04