Effect of MOPs During Orthodontic Movement in Periodontitis Patients
Eligible age
18–80 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
No
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About this study
Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. It remains unclear the effect of orthodontic intrusion combined with MOPs application on teeth with reduced periodontium. The general objective will be to determine the efficacy of MOPs during orthodontic tooth movement (OTM) in terms of periodontal and orthodontic outcomes in stage IV periodontitis patients, case type 2 with pathological tooth migration (PTM), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \<5mm)
Sponsor: Universidad Complutense de Madrid
You may qualify if…
- ✓ Patients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage IV periodontitis patients, and fulfilling the following criteria:
- ✓ adult patients older than 18-year-old;
- ✓ systemically healthy (see exclusion criteria);
- ✓ diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis;
- ✓ the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \<5mm) (experimental teeth);
- ✓ in need of orthodontic therapy.
You may not qualify if…
- ✕ systemic diseases (diabetes mellitus, obesity, cardiovascular diseases);
- ✕ any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers);
- ✕ pregnant or lactating woman;
- ✕ inability to respond questions or to attend follow-up visits;
- ✕ extreme skeletal malocclusions requiring orthognathic surgery;
- ✕ patients smoking more than 10 cigarettes/day; and
- ✕ the presence of PD greater or equal to 5mm with BOP after step 3 of periodontal therapy
Source: ClinicalTrials.gov · NCT06068270 · last updated 2025-03-27