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RecruitingTraumatic Brain InjuryCognitive DeclineVascular Dementia

Cognitive and Vascular Functioning Following TBI

Eligible age

18–74 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging data

Sponsor: Walter Reed National Military Medical Center

You may qualify if…

  • ✓ 1. Active duty uniformed SM or Veteran who is currently eligible for treatment at WRNMMC (i.e., Defense Enrollment Eligibility Reporting System (DEERS)-eligible).
  • ✓ 2. Ability to read, write, and speak English.
  • ✓ 3. Ability to provide informed consent.
  • ✓ 4. NICoE Intensive Outpatient Program (IOP) or NatHx Study comprehensive evaluation ≥3 years prior to current evaluation with valid neuropsychological test results.
  • ✓ 5. Consent to allow access to prior research data collected through the NICoE TBI Neuroimaging Core Project or NatHx Study and consent to allow access to at least 1 prior blood specimen previously collected through these studies or the DoD Serum Biorepository.
  • ✓ Additional TBI Inclusion Criteria
  • ✓ 1\. History of at least one mild, moderate, severe, or penetrating TBI \> 3 years prior to enrollment. TBI will be diagnosed if any one of the following criteria immediately after the injury is met and attributed to the brain injury, rather than environmental/psychological/other injury factors (DoD-VA criteria246):
  • ✓ 1. Loss of consciousness (LOC) or post-traumatic amnesia (PTA)

You may not qualify if…

  • ✕ 1. Disabling neurologic or psychological disorders such as autism, cerebral palsy, developmental disorder, stroke, brain tumor, multiple sclerosis, meningitis, encephalitis, brain abscess, vascular malformation, pre-injury epilepsy, schizophrenia, bipolar disorder, personality disorder
  • ✕ 2. Diabetes mellitus requiring drug treatment
  • ✕ 3. Hypertension requiring more than 1 antihypertensive drug to control BP
  • ✕ 4. History of myocardial infarction or other systemic vasculopathies
  • ✕ 5. Dementia diagnosis at initial NICoE/NatHx Study assessment

Where it's recruiting

Maryland

Bethesda

Source: ClinicalTrials.gov · NCT06034509 · last updated 2025-09-26

Cognitive and Vascular Functioning Following TBI · TrialPath