CogT pSOPT Intervention Study
Eligible age
60+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
(JUSTIFICATION: This is the R33 stage of an NIH funded R21/R33 study. R21 stage (IRB-61727) was focused on intervention development; R33 stage will focus on pilot testing the effect of the intervention. The R21 phase was not considered a NIH defined clinical trial; R33 will be considered a NIH defined clinical trial) The purpose is to develop and test the effect of a "personalized" computer-based cognitive training program. The personalized program tailors the difficulty of the training tasks using a participant's biofeedback (i.e., heart rate) and cognitive performance. Such a personalization will ensure that the participant can perform at his/her ideal training capacity. Participants will be randomized into one of 2 groups and each group will play a different version of computerized training game and have ECG collected to allow subject blinding.
Sponsor: Stanford University
You may qualify if…
- ✓ 1. criteria related to defining "mild cognitive impairment": a. Presence of memory complaint; b. Rey Auditory Verbal Learning Test delayed recall (for memory) \< 59% of age-adjusted norm; c. Montreal Cognitive Assessment (for global cognition) ranged 18 and 27; d. Functional Assessment Questionnaire (for activities of daily living) \< 20.
- ✓ 2. intact score for San Diego Brief Assessment of Capacity to Consent (UBACC).
- ✓ 3. if a participant is on AD medication (i.e., memantine, cholinesterase inhibitors, amyloid antibodies), antidepressants, anxiolytics, or vascular risk or diseases related medications (e.g., beta-blocker), the dose should be stable for 3 months prior to recruitment.
- ✓ 4. age 60+,
- ✓ 5. read and understand English
- ✓ 6. adequate visual and hearing acuity for testing by self-report,
- ✓ 7. community-dwelling (including independent living).
You may not qualify if…
- ✕ 1. current enrollment in another cognitive improvement study;
- ✕ 2. uncontrollable major depression;
- ✕ 3. major cerebrovascular and cardiovascular diseases (e.g., congestive heart failure, pacemaker, prior myocardial infarction);
- ✕ 4. having an active legal guardian (indicating impaired capacity for decision making);
- ✕ 5. currently pregnant
- ✕ 6. 3T MRI contraindication
- ✕ 7. Neurological conditions: Neurodegenerative disease diagnosis such as Parkinson's, Alzheimers, dementia, multiple sclerosis. Of note, other neurological conditions/injury such as stroke, seizures, traumatic brain injury, will be evaluated for inclusion/exclusion on a case-by-case basis based on event recency, severity, and recovery.
Where it's recruiting
Palo Alto
Source: ClinicalTrials.gov · NCT06005038 · last updated 2024-05-17