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RecruitingObstructive Sleep Apnea

Endotypic Traits and Obstructive Sleep Apnea Surgery

Eligible age

21+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).

Sponsor: University of California, Los Angeles

You may qualify if…

  • ✓ 1. age ≥21 years;
  • ✓ 2. moderate to severe OSA (obstructive AHI ≥ 15 events/hour);
  • ✓ 3. central/mixed apnea index \<5 events/hour;
  • ✓ 4. intolerance of positive airway pressure (defined as use \< 2 hours/night at least 5 nights/week);
  • ✓ 5. intolerance or poor candidate for oral appliance;
  • ✓ 6. participant has provided informed consent for palate surgery as part of their standard of care;
  • ✓ 7. tonsil size 0-2+ (without markedly enlarged tonsils that have high surgical success rates);
  • ✓ 8. DISE without evidence of complete tongue-related obstruction (reflecting poorer results with isolated palate surgery);

You may not qualify if…

  • ✕ 1. history of allergic reaction to either of the study drugs;
  • ✕ 2. subjects with prior serious allergic reaction (such as Stevens-Johnson syndrome) to sulfonamides;
  • ✕ 3. subjects with a history of hypersensitivity to either of the two study drugs;
  • ✕ 4. subjects who are on high-dose aspirin therapy due to risk of severe metabolic acidosis;
  • ✕ 5. subjects with severe kidney disease or severe liver disease;
  • ✕ 6. subjects with a history of electrolyte imbalance or adrenal insufficiency (due to risks related to acetazolamide);
  • ✕ 7. subjects on ketoconazole or other strong CYP3A4 inhibitors (these will increase eszopiclone blood levels);
  • ✕ 8. pregnancy; and

Where it's recruiting

California

Santa Monica · Westwood, Los Angeles

Source: ClinicalTrials.gov · NCT05953610 · last updated 2025-06-27

Endotypic Traits and Obstructive Sleep Apnea Surgery · TrialPath