RecruitingGlaucoma
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial
Eligible age
18+ yrs
Accepts
All genders
Locations
6 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial (DECLARE) is a multi-center, outcome-masked, randomized clinical trial. The purpose of this study is to compare glaucoma drainage device implantation in the anterior chamber (front part of the eye) and sulcus (small space between iris and front chamber of the eye) in efforts to minimize cell loss in the eye.
Sponsor: University of Pennsylvania
You may qualify if…
- ✓ Medically uncontrolled glaucoma requiring GDD or GDD combined with phacoemulsification as the planned surgical procedure
- ✓ Candidate for GDD implantation for ciliary sulcus and AC tube
- ✓ Age greater than or equal to 18 years old
You may not qualify if…
- ✕ Preexisting corneal condition that would affect the corneal endothelium or previous corneal transplant
- ✕ Presence or history of Cypass Micro-Stent
- ✕ Previous GDD, Xen Gel Stent or Preserflo MicroShunt removed less than 6 months before surgery
- ✕ Presence of GDD implantation, Xen Gel Stent, of Preserflo MicroShunt
- ✕ Previous trabeculectomy and/or minimally invasive glaucoma surgery within the past 6 months
- ✕ AC intraocular lens
- ✕ Presence of nanophthalmos, uncontrolled uveitis, silicone oil, Sturge-Weber syndrome or other conditions associated with elevated episcleral venous pressure
- ✕ Unwilling or unable to give consent, unwilling to accept randomization, or unable to return for scheduled protocol visits
Where it's recruiting
California
San Francisco · Walnut Creek
Florida
Miami
Maryland
Baltimore
Massachusetts
Boston
New York
Buffalo
North Carolina
Chapel Hill
Source: ClinicalTrials.gov · NCT05924477 · last updated 2025-06-27