Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Eligible age
18+ yrs
Accepts
All genders
Locations
3 states
Healthy volunteers
No
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About this study
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.
Sponsor: Rush University Medical Center
You may qualify if…
- ✓ 1. Adult, age ≥ 18 years old
- ✓ 2. Receiving invasive mechanical ventilation for ≥24 hours
- ✓ 3. BMI ≥40 kg/m2
- ✓ 4. Undergoing planned extubation per treating team
- ✓ 5. Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT)
You may not qualify if…
- ✕ 1. Pregnant
- ✕ 2. Use of extra-corporeal membrane oxygenation
- ✕ 3. Chronic tracheostomy in place
- ✕ 4. Unplanned or accidental extubation
- ✕ 5. Terminal/compassionate extubation
- ✕ 6. Contraindication to NIV use
- ✕ 7. Intubated because of an acute exacerbation of COPD
- ✕ 8. Underlying neuromuscular disease
Where it's recruiting
Source: ClinicalTrials.gov · NCT05918575 · last updated 2025-10-20