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RecruitingSpinal Cord Injury at C5-C7 LevelSpinal Cord InjuriesSpinal Cord Injury Cervical

Grasp-Release Assessment of a Networked Neuroprosthesis Device

Eligible age

16+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.

Sponsor: MetroHealth Medical Center

You may qualify if…

  • ✓ Male or female, age \> 16 years.
  • ✓ Cervical level spinal cord injury, as defined by:
  • ✓ 1. International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor level of C1 through C7 and
  • ✓ 2. American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, or C;
  • ✓ Six months or more post-injury (neurostability);
  • ✓ Neurologically stable following any nerve transfers affecting the upper extremity (typically, one year post surgery);
  • ✓ Musculoskeletally and neurologically stable following any tendon transfers affecting the upper extremity (typically, 6-months).
  • ✓ Peripheral nerve innervation to upper extremity muscles, including a grade 3/5 or higher Stimulated Manual Muscle Test (SMMT) strength in at least two of the following muscles in one arm:

You may not qualify if…

  • ✕ Other neurological conditions (MS(multiple Sclerosis), diabetes with peripheral nerve involvement); Associated peripheral nerve / brachial plexus injury
  • ✕ Progressive SCI;
  • ✕ Co-existing cervical spine pathology (syrinx, unstable segment)
  • ✕ Active implantable medical device (AIMD) such as a pacemaker or defibrillator;
  • ✕ Active untreated infection such as pressure injury, urinary tract infection, pneumonia;
  • ✕ History of coagulopathy, HIV, cardiopulmonary disease, bradycardia, poorly controlled autonomic dysreflexia, or chronic obstructive pulmonary disease that would preclude safe participation in the trial as determined by the investigator;
  • ✕ Unhealed fractures that prevent functional use of arm;
  • ✕ Extensive upper extremity denervation (fewer than two excitable hand muscles);

Where it's recruiting

Ohio

Cleveland

Source: ClinicalTrials.gov · NCT05863754 · last updated 2025-12-19

Grasp-Release Assessment of a Networked Neuroprosthesis Device · TrialPath