RecruitingCommunity-acquired Pneumonia
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
Eligible age
18+ yrs
Accepts
All genders
Locations
7 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs. usual care pharmacological thromboprophylaxis on outcomes in patients admitted to hospital with community acquired pneumonia (CAP).
Sponsor: University of Manitoba
You may qualify if…
- ✓ 1. Patients ≥18 years of age
- ✓ 2. Admitted to hospital for a suspected or confirmed diagnosis of CAP defined by:
- ✓ 1. Radiographic evidence of new or worsening infiltrate
- ✓ 2. One or more of the following signs and/or symptoms of lower respiratory tract infection
- ✓ i. New or increased cough or sputum production ii. Fever of \> 37.8C or temperature \< 36C iii. WBC \> 11 x 109/L or \< 4 x 109/L c. The primary diagnosis is believed to be CAP as per the attending physician
- ✓ 3. Requires supplemental oxygen to treat hypoxemia (or requires an increased level of supplemental oxygen if on chronic oxygen therapy)
- ✓ 4. Hospital admission anticipated to last ≥72 hours from randomization
You may not qualify if…
- ✕ 1. Suspected or confirmed active COVID-19 infection
- ✕ 2. Hospital admission for \>72 hours prior to randomization
- ✕ 3. Patients receiving non-invasive or invasive ventilation, vasopressors, or extracorporeal life support (ECLS) within an ICU at the time of enrollment
- ✕ 4. Requirement for chronic mechanical ventilation via tracheostomy prior to hospitalization
- ✕ 5. Patients for whom the intent is to not use pharmacologic thromboprophylaxis
- ✕ 6. Patients with an independent indication for therapeutic-dose anticoagulation
- ✕ 7. Patients with a contraindication to therapeutic-dose anticoagulation, including:
- ✕ 1. Non-traumatic bleeding that requires medical evaluation or hospitalization within 30 days prior to CAP hospital admission
Where it's recruiting
Illinois
Chicago
Louisiana
Jefferson
Maine
Portland
Michigan
Dearborn
New Jersey
Camden
South Carolina
São José
Wisconsin
Milwaukee
Source: ClinicalTrials.gov · NCT05848713 · last updated 2026-04-21