RecruitingAnginaStable Ischemic Heart Disease
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
Eligible age
65+ yrs
Accepts
All genders
Locations
8 states
Healthy volunteers
No
See if you qualify for this study
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About this study
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).
Sponsor: Yale University
You may qualify if…
- ✓ OLDER ADULTS WITH SIHD AND MCC
- ✓ Age ≥65 years
- ✓ ≥ 2 Multiple Chronic Conditions as defined by Centers for Medicare and Medicaid Services (CMS)
- ✓ Diagnosis of Symptomatic Stable Ischemic Heart Disease with plans to initiate medical therapy identified by at least one of the following:
- ✓ 1. positive non-invasive functional or anatomic testing suggestive of obstructive coronary artery disease
- ✓ 2. coronary angiography with stenosis ≥70% in a coronary artery ≥2 mm in diameter or
- ✓ ≥50% stenosis of left main
- ✓ 3. Invasive coronary angiography with positive physiologic testing in at least one vessel (FFR ≤ 0.80 or iFR ≤0.89)
You may not qualify if…
- ✕ OLDER ADULTS WITH SIHD AND MCC
- ✕ Current taking (both) a beta-blocker AND a calcium channel blocker\*
- ✕ Contraindication to beta-blockers or calcium channel blockers including:
- ✕ 1. significant hypotension
- ✕ 2. high grade AV block
- ✕ 3. severe symptomatic bradycardia
- ✕ 4. severe obstructive lung disease
- ✕ Documented intolerance to beta-blockers or calcium channel blockers
Where it's recruiting
Connecticut
New Haven
Georgia
Marietta
Illinois
Chicago
Massachusetts
Boston
New York
New York
North Carolina
Durham
Ohio
Cleveland
Virginia
Fairfax
Source: ClinicalTrials.gov · NCT05786417 · last updated 2026-04-07