Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)
Eligible age
18–60 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The goal of this clinical trial is to learn about the effects of high blood glucose levels in the brain and assess if the changes seen in individuals with poorly control T2DM can be reversed with good glucose control. The main question\[s\] it aims to answer are: * To determine, whether abnormalities in brain glucose transport seen in individuals with uncontrolled diabetes, can be improved with better glucose control. * Assess which factors, (duration of diabetes mellitus (DM) and glycemic control) contribute to changes in glucose transport Participants will have: * A screening visit * placement of a continuous glucose monitor (CGM) 2 weeks before the first magnetic resonance spectroscopy (MRS) at week 0 * Additional visits/phone calls for intensification of diabetes management and nutrition visits * Second magnetic resonance spectroscopy (MRS) at week 12
Sponsor: Yale University
You may qualify if…
- ✓ Provision of signed and dated informed consent form
- ✓ Stated willingness to comply with all study procedures and availability for the duration of the study
- ✓ Male or female, aged 18-60
- ✓ medical history for Type 2 diabetes
- ✓ HbA1c \> 7.5%, BMI ≥18 kg/m2
- ✓ Be willing to adhere to the intensification of their diabetes regimen
You may not qualify if…
- ✕ Creatinine \> 1.5 mg/dL
- ✕ Hgb \< 10 mg/dL, hematocrit of 37 % for males participants and 33 % for female participants
- ✕ ALT \>3 x ULN
- ✕ untreated thyroid disease,
- ✕ uncontrolled hypertension
- ✕ known neurological disorders
- ✕ untreated psychiatric disorders
- ✕ malignancy
Where it's recruiting
New Haven
Source: ClinicalTrials.gov · NCT05776563 · last updated 2025-01-14