A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program
Eligible age
25–59 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity following participation in a behavioral weight loss program. Eligible participants will undergo a baseline evaluation after which they will enter an up to 20 week behavioral weight loss program with the goal of losing at least 7 percent of their baseline weight within 35 weeks. Participants who meet the weight loss goal will be asked to remain weight stable for 2 weeks after which they will undergo a clinical examination. They will then be observed for 1 year during which they will undergo 2 additional clinical examinations, one 4 months after completing the weight loss program, and the other 12 months after completing the weight loss program.
Sponsor: University of Pittsburgh
You may qualify if…
- ✓ 1. Age: 25 - \<60 years
- ✓ 2. BMI: 30 - \<40 kg/m2 at the first screening visit
- ✓ 3. Within 5% of current weight, for the past 6 months at the first screening visit
- ✓ 4. Able to participate in ergometry testing
- ✓ 5. Has a smart phone, tablet or computer with access to the internet
You may not qualify if…
- ✕ 1. If 25-29 years old, \> 5% deviation from maximum weight (excluding weights while pregnant) since age 25 years
- ✕ 2. If at least 30 years old, \> 5% deviation from maximum weight (excluding weights while pregnant) in last 5 years or ≥ 10% deviation from maximum weight (excluding weights while pregnant) since age 30 years
- ✕ 3. History of pulmonary embolus in the past 6 months
- ✕ 4. Cardiovascular disease (e.g. myocardial infarction, stroke, hospitalization for unstable angina, or transient ischemic attack) within the past 6 months
- ✕ 5. Current major depressive disorder or history of major depressive disorder within 2 years
- ✕ 6. Any regular tobacco or nicotine use in the past year
- ✕ 7. Currently engaging in intense physical training or training for a sports event including, but not limited to, a marathon or body building
- ✕ 8. Currently pregnant, or less than one-year post-partum or actively planning to become pregnant within the next two years
Where it's recruiting
New York
Philadelphia
Source: ClinicalTrials.gov · NCT05748158 · last updated 2026-06-12