RecruitingCystic FibrosisCystic Fibrosis-related DiabetesCystic Fibrosis With Intestinal Manifestations
The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes
Eligible age
18–70 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
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About this study
This study will evalute the effect of a low glycemic load (LGL diet on dysglycemia, insulin requirements, DXA-derived body composition, gastrointestinal symptoms and quality of life measures in adults with cystic fibrosis-related diabetes (CFRD). We will use continuous glucose monitors (CGM) to assess the LGL diet both in a controlled setting (via a meal delivery company) and in free-living conditions.
Sponsor: Rhode Island Hospital
You may qualify if…
- ✓ 18 years and above
- ✓ Genetically confirmed diagnosis of CF
- ✓ Diagnosis of pancreatic insufficiency, requiring pancreatic enzyme replacement
- ✓ Criteria for CFRD:
- ✓ A.) Most recent OGTT 2-hour glucose \>200 mg/dL within the past two years, and/or; B.) HbA1c \>6.5% in the past two years, and/or; C.) Current use of insulin
You may not qualify if…
- ✕ FEV1 \<50% predicted on most recent pulmonary function testing
- ✕ BMI \<18 kg/m2
- ✕ Currently receiving enteral nutrition support via GT feeds
- ✕ Pregnancy, plan to become pregnant in the next 3-months, or sexually active without use of contraception
- ✕ Use of IV antibiotics or systemic supraphysiologic glucocorticoids for CF exacerbation within 1 month
- ✕ Started or stopped treatment with a CFTR modulator within 3 months of enrollment
- ✕ Currently adhering to an LGL or other carbohydrate-restricted diet (carbohydrate intake \<30% of total daily caloric intake)
Where it's recruiting
Massachusetts
Boston
Rhode Island
Providence
Source: ClinicalTrials.gov · NCT05723445 · last updated 2025-08-22