Identifying Markers of Exercise Training in Heart Failure
Eligible age
18–89 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The heart failure syndrome that occurs when the heart is too sick to properly do its job. One of the main symptoms is difficulty with exercise. One way to improve symptoms is to start patients in a 12 week exercise program called cardiac rehabilitation. Cardiac rehabilitation been shown to improve symptoms for heart failure patients. However, the investigators do not know exactly what exercise does to the molecules that make up the human body. If the investigators could answer this question, the investigators might find a whole new way to treat the symptoms of heart failure. Therefore the investigators want to know what molecules might be responsible for the benefits of exercise. The plan for this study is to measure the levels of thousands of proteins in blood samples which come from people with heart failure and see how those levels change after 12 weeks of cardiac rehabilitation, compared to the protein levels in patients whose cardiac rehabilitation is delayed until after the study period. If the investigators know the proteins that change with exercise, the investigators can then look to see if targeting these proteins with medicines can mimic the benefits of exercise. The long term goal of our work is to identify "exercise-in-a-pill" medicines that will help people with heart failure.
Sponsor: Stanford University
You may qualify if…
- ✓ Provision of signed and dated informed consent form
- ✓ Stated willingness to comply with all study procedures and availability for the duration of the study
- ✓ Male or female, aged 18-89
- ✓ Patients must carry a diagnosis of heart failure with ejection fraction \< 40%
- ✓ Be willing to participate in cardiac rehabilitation, and not already done so in the last year
- ✓ Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration
- ✓ Must be able to exercise on a treadmill
You may not qualify if…
- ✕ Inability to complete CPET or participate in CR (verbal/chart)
- ✕ Syncope during CPET within the last 6 mos, sustained VT on CPET, hemodynamically significant arrhythmia during CPET (verbal/chart)
- ✕ BMI \>= 38 (verbal/chart)
- ✕ History of a bleeding disorder or clotting abnormality (verbal/chart)
- ✕ Clinical diagnosis of severe Chronic Obstructive Pulmonary Disease (COPD) (verbal/chart)
- ✕ History of malignancy not considered in remission (verbal/chart)
- ✕ Cirrhosis (verbal/chart)
- ✕ Thyroid disease (verbal/chart)
Where it's recruiting
Stanford
Source: ClinicalTrials.gov · NCT05696652 · last updated 2026-02-13