RecruitingCADASIL

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

Eligible age

18+ yrs

Accepts

All genders

Locations

10 states

Healthy volunteers

Yes

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About this study

This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.

Sponsor: University of Wisconsin, Madison

You may qualify if…

✓ 1. Must be at least 18 years old
✓ 2. Positive NOTCH3 genetic testing; OR a positive skin biopsy; OR a willingness to have a NOTCH3 genetic test completed prior to enrolling AND are at-risk for, or diagnosed clinically with, CADASIL
✓ 3. Willing to commit to three in-person visits (a baseline visit, an 18-month follow-up, and a 36-month follow-up) and to remote visits as needed by phone, email, mail or internet
✓ 4. Willing to provide documentation of all current medications to study team
✓ a. All medications will be allowed throughout the course of study. Documentation of medications will be used for analyses to assess potential impact of medications on study outcomes.
✓ 5. Willing and able to undergo an MRI scan and blood draw at each in-person visit
✓ 6. Must have a designated "study companion"
✓ a. A "study companion" is someone who knows the participant well (has greater than or equal to 3 hours/month of contact with the CADASIL participant) and can provide additional information to the study team (either remotely or in-person).

You may not qualify if…

✕ 1. History of severe learning disability, intellectual disability, or other neurological disease or event not attributable to CADASIL
✕ 2. History of serious alcohol or drug abuse within the past year
✕ 3. Unwilling to undergo NOTCH3 genetic testing if there is no test on file