RecruitingMajor Depressive Disorder
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
Eligible age
18–45 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This study looks at the role of the Nociceptin/Orphanin FQ receptor system in the brain of individuals with current or past major depressive disorder (MDD). It also examines how individuals with a history of depression make certain decisions and which brain regions are involved in such decisions. Information collected through MRI, PET, biospecimens (i.e., blood, saliva) and behavioral tasks will be used to predict depressive symptoms in the future.
Sponsor: Mclean Hospital
You may qualify if…
- ✓ All genders, races, and ethnic origins, aged between 18 and 45
- ✓ Capable of providing written informed consent, and fluent in English
- ✓ Right-handed
- ✓ Absence of any psychotropic medications for at least 2 weeks
- ✓ Has a smartphone (iPhone or Android) (needed for Ecological Momentary Assessment)
- ✓ Meets inclusion criteria for all subjects, plus:
- ✓ History of MDD as defined by DSM-5
- ✓ Absence of anxiety disorder for the past two months
You may not qualify if…
- ✕ Subjects with suicidal ideation where outpatient treatment is determined unsafe by the study clinician. These patients will be immediately referred to appropriate clinical treatment
- ✕ Pregnant women or women of childbearing potential who are not using a medically accepted means of contraception (defined as oral contraceptive pill or implant, condom, diaphragm, spermicide, IUD, s/p tubal ligation, or partner with vasectomy)
- ✕ Serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
- ✕ History of seizure disorder
- ✕ History of psychiatric illnesses, other than depression or anxiety disorders among the Current MDD and Remitted MDD groups
- ✕ History of substance use disorder or alcohol use disorder (as these terms are defined by DSM-5); except depressed subjects may have a history of 'Mild' substance/alcohol use disorder only if it ended as least 12 months ago
- ✕ History of cocaine or stimulant use or dopaminergic drugs
- ✕ History or current diagnosis of dementia, or a score of \< 26 on the Mini Mental State Examination at the screening visit;
Where it's recruiting
Massachusetts
Belmont
Source: ClinicalTrials.gov · NCT05630963 · last updated 2025-10-21