RecruitingDementia
Ruijin Neurobank of Alzheimer's Disease and Dementia
Eligible age
50–90 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The goal of this observational study is to learn about neuroimage and biomarkers in the Alzheimer's continuum. The main questions it aims to answer are: * How is the neurovascular coupling during AD pathogenesis? * How is the pattern/mapping of alterations in AD biomarkers? Participants will be observed and visit the research center annually to perform multi-modal MRI, PET, neuropsychological tests, and blood tests.
Sponsor: Ruijin Hospital
You may qualify if…
- ✓ 1. Male and female aged 50 to 90 years old;
- ✓ 2. In accordance with the diagnostic criteria for "mild cognitive impairment due to Alzheimer's disease" and "Dementia" from the National Institutes of Health National Institute on Aging-Alzheimer's Association (NIA-AA) (2011);
- ✓ 3. The Hamilton depression rating scale/17 edition (HAMD) total score\<10;
- ✓ 4. The clinical dementia rating (CDR) is 0.5 or above;
- ✓ 5. Neurological examination: no obvious signs;
- ✓ 6. Participants should have a caregiver stable and reliable.
- ✓ 7. Education: primary school (grade 6) or above. They have the ability to complete tests for cognitive ability and have the ability and time to complete regulation of cognitive training
You may not qualify if…
- ✕ 1. Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, CJD, Huntington's and Parkinson's disease, DLB, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), systemic disease (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial occupation (a subdural hematoma, brain tumor), the endocrine system disease (thyroid disease, parathyroid disease), and vitamins deficiency or any other causes of dementia.
- ✕ 2. The history of nervous system diseases, including stroke, optic myelitis, Parkinson's disease, epilepsy, etc.);
- ✕ 3. Psychiatric patients, including schizophrenia or other mental illnesses, bipolar disorder, major depression, or delirium;
- ✕ 4. There are unstable or serious heart, lung, liver, kidney, and hematopoietic system diseases; Poor prognosis because of malignant diseases such as tumors.
- ✕ 5. Vision or hearing problems that lead to poor performance on cognitive tests;
- ✕ 6. Two years history of severe alcoholism, and drug abuse;
- ✕ 7. The researchers believe that the subjects could not complete the study.
- ✕ 8. Contraindication of MRI or PET scanning.
Source: ClinicalTrials.gov · NCT05623124 · last updated 2024-11-25