RecruitingLung CancerGenetic DiseaseGenetic Predisposition
Investigating Hereditary Risk In Thoracic Cancers (INHERIT)
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
The purpose of this research study is to learn more about the inherited risk for developing lung cancer.
Sponsor: Dana-Farber Cancer Institute
You may qualify if…
- ✓ Cohort 1: individuals with or with high risk of carrying an EGFR T790M or other EGFR germline variant identified in blood or saliva, including via somatic single or multi-gene panel testing (MGPT). This includes both probands and family members.
- ✓ Participants with variants of uncertain significance may be eligible at the PI's discretion
- ✓ Cohort 2: individuals with or with high risk of carrying non-EGFR germline variants suggestive of a potential inherited lung cancer risk, identified in blood or saliva, including via somatic single or multi-gene panel testing (MGPT). This includes both probands and family members.
- ✓ Participants with variants of uncertain significance may be eligible at the PI's discretion
- ✓ Cohort 3: individuals with lung cancer who are not known to carry a pathogenic or likely pathogenic variant, and with one of the following:
- ✓ first-degree relative with lung cancer
- ✓ multi-generational family history of lung cancer
- ✓ personal history of multiple primary lung cancers or other neoplasms
You may not qualify if…
- ✕ Individuals who decline to consent
- ✕ Individuals who are unable to give consent or assent and are without a designated healthcare proxy
Where it's recruiting
Massachusetts
Boston
Source: ClinicalTrials.gov · NCT05587439 · last updated 2025-07-10