RecruitingSpinal Cord Injuries
Combination Therapy to Improve SCI Recovery.
Eligible age
18–70 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.
Sponsor: Spaulding Rehabilitation Hospital
You may qualify if…
- ✓ 18 to 70 years of age
- ✓ medically stable with medical clearance from study physician to participate
- ✓ SCI at or below C2 (phrenic sparing) and at or above L2 with at least some sensory or motor function preserved below the neurologic level
- ✓ non-progressive etiology of spinal injury
- ✓ American Spinal Injury Association (ASIA) scores of C-D at initial screen
- ✓ ambulatory (able to complete the 10-meter walk test without support from another person)
- ✓ chronic injury (define as \> 12 months post-injury) to avoid potential for spontaneous neurological plasticity and recovery
You may not qualify if…
- ✕ severe concurrent illness or pain, including unhealed decubiti, severe neuropathic or chronic pain syndrome, severe infection (e.g., urinary tract), hypertension, cardiovascular disease, pulmonary disease, severe osteoporosis, active heterotopic ossification in the lower extremities, severe systemic inflammation
- ✕ \< 24 on Mini-Mental Exam
- ✕ severe recurrent autonomic dysreflexia
- ✕ history of severe cardiovascular/pulmonary complications including hypertension (systolic blood pressure \> 150 mmHg)
- ✕ pregnancy because of unknown effects of AIH or tSTIM on a fetus (individuals of childbearing potential will not otherwise be excluded)
- ✕ botulinum toxin injections in lower extremity muscles within the prior three months
- ✕ history of tendon or nerve transfer surgery in the lower extremity
- ✕ untreated severe sleep-disordered breathing characterized by uncontrolled hypoxia and sleep fractionation that may impact the outcome of this study.
Where it's recruiting
Illinois
Chicago
Massachusetts
Cambridge
Source: ClinicalTrials.gov · NCT05563103 · last updated 2026-03-20