RecruitingBreast Carcinoma
Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer
Eligible age
18–45 yrs
Accepts
Women
Locations
5 states
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This phase II trial tests whether low-dose aspirin can affect markers of inflammation in postpartum (after childbirth) women planning to have a breast biopsy. Chronic inflammation may increase the risk of postpartum related breast cancer. Low-dose aspirin is a non-steroidal anti-inflammatory drug. Giving low-dose aspirin may affect markers of inflammation in blood and tissue and may prevent postpartum related breast cancer.
Sponsor: Mayo Clinic
You may qualify if…
- ✓ PRE-REGISTRATION: Age \>= 18 years and =\< 45 years of age
- ✓ PRE-REGISTRATION: Willingness to provide mandatory tissue specimens for correlative research at two timepoints.
- ✓ PRE-REGISTRATION: Had a live birth =\< 10 years prior to pre-registration
- ✓ PRE-REGISTRATION: Pre-menopausal according to patient report and/or clinical determination
- ✓ PRE-REGISTRATION: Provide written informed consent
- ✓ PRE-REGISTRATION: Ability to complete questionnaire(s) by themselves or with assistance
- ✓ PRE-REGISTRATION: Willingness to provide mandatory blood and urine specimens for correlative research
- ✓ REGISTRATION: Age \>= 18 years and =\< 45 years of age
You may not qualify if…
- ✕ PRE-REGISTRATION: History of breast cancer including ductal breast carcinoma in situ (DCIS)
- ✕ PRE-REGISTRATION: Received systemic treatment for any other cancer at any time
- ✕ PRE-REGISTRATION: Currently taking aspirin or other non-steroidal anti-inflammatory drugs (NSAIDS) (no doses within =\< 5 days prior to pre-registration and no more than four doses within =\< 30 days prior to pre-registration)
- ✕ PRE-REGISTRATION: Currently taking other agents for the prevention of breast cancer
- ✕ PRE-REGISTRATION: Currently taking anticoagulants
- ✕ PRE-REGISTRATION: Contraindication for aspirin use
- ✕ PRE-REGISTRATION: Known or suspected active breast infection
- ✕ REGISTRATION: Known DCIS or invasive cancer
Where it's recruiting
Source: ClinicalTrials.gov · NCT05557877 · last updated 2026-08-20