Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualized treatments for depression.
Sponsor: Massachusetts General Hospital
You may qualify if…
- ✓ 18-65 years of age
- ✓ Capacity to provide informed consent form to participate in the study
- ✓ 18-65 years of age
- ✓ Capacity to provide informed consent form to participate in the study
- ✓ Currently in a major depressive episode. Comorbid anxiety disorders and personality disorders will be allowed provided that MDD is the primary diagnosis.
You may not qualify if…
- ✕ Meeting criteria, in the past or currently, for bipolar affective disorder, hypomania or mania.
- ✕ Meeting criteria, in the past or currently, for a primary psychotic disorder (e.g., schizophrenia).
- ✕ Neurological conditions with known structural brain lesions, e.g., intracranial masses, multiple sclerosis.
- ✕ Any personal history of seizures or a family history of epilepsy in a first-degree relative.
- ✕ Metal in the body that is ferromagnetic or metallic injury to the eyes.
- ✕ Implanted pacemakers, medication pumps, vagal stimulators, deep brain stimulators, or ventriculoperitoneal shunts, etc.
- ✕ Substance abuse or dependence that is current and active within the last six months, as indicated by self-report (e.g., heroin, cocaine, methamphetamines).
- ✕ Inability to meet the safety criteria for MRI scanning for any other reason.
Where it's recruiting
Boston
Source: ClinicalTrials.gov · NCT05523817 · last updated 2025-09-29