Assessment for Implementation Methods in Sepsis
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis "bundles" (3-hour bundle) and improved survival. The current proposal is a Hybrid 2, pragmatic, cluster randomized clinical effectiveness/implementation trial evaluating mortality and respiratory failure-based outcomes, in patients admitted to the emergency department with sepsis, comparing the effectiveness of implementation of the hour-1 bundle to 3-hour bundle, while facilitating adherence to both bundles. In addition, 4 distinct sepsis phenotypes will be derived from routine clinical data to identify specific patient phenotypes that allow for a more precision-based application of sepsis bundles in future studies.
Sponsor: Rhode Island Hospital
You may qualify if…
- ✓ Adults \>=18
- ✓ Patient meets criteria for time zero (sepsis within 6 hours of ED triage and the 3 criteria-infection, 2 SIRS and 1 or more organ dysfunctions, must be met within 3 hours of each other.
You may not qualify if…
- ✕ Last admission for patients admitted to same hospital once
- ✕ Pregnant women
- ✕ All transfers from another hospital
- ✕ Individuals who are made comfort care only within 6 hours of admission to ED
- ✕ Moribund patients
Where it's recruiting
Providence
Source: ClinicalTrials.gov · NCT05491941 · last updated 2022-08-08