Decoding and Modulating Affective Brain States
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.
Sponsor: University of Pennsylvania
You may qualify if…
- ✓ 1. 18-65 years old
- ✓ 2. Patient Health Questionnaire (PHQ-9 score) = or \> than 10
- ✓ 3. Comprehension of instructions in the English language.
- ✓ 4. Capacity to provide informed consent and follow study procedures.
- ✓ 5. Availability for the duration of the study.
You may not qualify if…
- ✕ 1. Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder
- ✕ 2. Recent use of psychoactive medications or substances as determined by investigators
- ✕ 3. History of neurological disorder or traumatic brain injury (other than mild)
- ✕ 4. Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
- ✕ 5. Unable to receive or tolerate TMS
- ✕ 6. Implanted devices, such as an aneurysm clip or cardiac pacemaker
- ✕ 7. History of stroke, epilepsy, or brain scarring
- ✕ 8. Pregnant, nursing, or trying to become pregnant (self-attestation alone)
Where it's recruiting
Philadelphia
Source: ClinicalTrials.gov · NCT05437705 · last updated 2026-09-03