RecruitingAnxiety DisordersTraumaGeneralized Anxiety Disorder
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxiety and its effects (PsyEd) will serve as a credible control comparator.
Sponsor: University of Texas at Austin
You may qualify if…
- ✓ 1. Clinically elevated anxiety as indicated by an eight or higher on the Overall Anxiety Severity and Impairment Scale (OASIS).
- ✓ 2. Meets DSM-5 criteria for one or more of the following anxiety or trauma-related disorders as their "primary" mental disorder:
- ✓ Generalized Anxiety Disorder
- ✓ Panic Disorder
- ✓ Health Anxiety
- ✓ Agoraphobia
- ✓ Social Anxiety Disorder
- ✓ Posttraumatic Stress Disorder
You may not qualify if…
- ✕ 1. No history of medical conditions that would contraindicate participation in fear-provocation or respiratory challenges, including:
- ✕ Cardiovascular or respiratory disorders
- ✕ High blood pressure
- ✕ Epilepsy
- ✕ Strokes
- ✕ Seizures
- ✕ History of fainting
- ✕ Pregnant or lactating
Where it's recruiting
Texas
Austin
Source: ClinicalTrials.gov · NCT05427708 · last updated 2025-08-24