RecruitingDepressive SymptomsMild Traumatic Brain InjuryConcussion
rTMS for Military TBI-related Depression
Eligible age
18–55 yrs
Accepts
All genders
Locations
3 states
Healthy volunteers
No
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About this study
The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a history of concussion/mild traumatic brain injury (TBI).
Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine
You may qualify if…
- ✓ Age 18-55 at the time of consent. Older individuals will not be enrolled in this initial trial for reasons of safety and expected reduced efficacy.
- ✓ Current or former US military service member eligible for care at a Military Treatment Facility (MTF) or Veterans Administration Medical Center (VAMC.)
- ✓ Able to provide written, informed consent in English .
- ✓ Self-reported or medically diagnosed history of concussion (synonymous with "mild TBI.") \>6 months, but \<26 years prior to consent, defined based on the DoD/VA definition:
- ✓ 1. Positive Loss of Consciousness of \<30 minutes as confirmed by the TBI Screener and/or medical records and/or;
- ✓ 2. Positive Alteration of Consciousness of \<24 hours as confirmed by the TBI Screener and/or medical records and/or;
- ✓ 3. Positive Post-traumatic Amnesia of 0 to 1 day as confirmed by the TBI Screener and/or medical records.
- ✓ Note: Neuroimaging data or documentation from medical records is not required.
You may not qualify if…
- ✕ Elevated risk of seizures at the time of rTMS including any of the following:
- ✕ 1. History of unprovoked seizures.
- ✕ 2. History of seizure within 24 hours of sustaining a concussion(s) or other head injury regardless of whether it was determined to have been related to concussion.
- ✕ 3. Family history of two or more unprovoked seizures in a first degree relative (parent, sibling, or child).
- ✕ 4. History of Moderate, Severe, or Penetrating TBI based on TBI Screener and/or medical records.
- ✕ 5. Intracranial lesion (such as intracranial tumor or intraparenchymal hemorrhage) that, in the opinion of the investigators, would increase seizure risk.
- ✕ 6. Currently taking medication or other substances (such as tricyclic antidepressants or neuroleptics) that, in the opinion of the investigator, lowers the seizure threshold.
- ✕ Contraindications to awake 3T MRI without contrast at the time of the Baseline MRI according to site radiology department criteria.
Where it's recruiting
Source: ClinicalTrials.gov · NCT05426967 · last updated 2026-04-29