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RecruitingAlzheimer DiseaseDementia of Alzheimer Type

Assess Fibrin in Brains With AD/ADRD

Eligible age

55–90 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.

Sponsor: Massachusetts General Hospital

You may qualify if…

  • ✓ Age between 55 and 90 years
  • ✓ Ability to provide informed consent
  • ✓ Specific to healthy volunteers: no history of ADRD
  • ✓ Specific to ADRD subjects: clinical diagnosis of AD - either amnestic or atypical, clinical severity ranging from MCI to moderate dementia (CDR 0.5-2.0), MMSE score greater than or equal to 15 and/or MOCA greater than or equal to 12
  • ✓ Specific to BAnD subjects: referred through the Brain Aging and Dementia (BAnD) research registry

You may not qualify if…

  • ✕ MR contraindications such as: electrical implants such as cardiac pacemakers or perfusion pumps; ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants, ferromagnetic objects such as jewelry or metal clips in clothing
  • ✕ Preexisting medical conditions including a likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest
  • ✕ Subjects whose estimated glomerular filtration rate (eGFR) \< 60 mL/min will be excluded from receiving the gadolinium-based contrast agent
  • ✕ Research-related radiation exposure exceeding current Massachusetts General Hospital (MGH) Radiology Department guidelines (i.e. 50 millisievert in the prior 12 months)
  • ✕ 3\. In line with published MGH IRB guidelines for pregnancy must be ruled out by urine ß-HCG if answers to screening questions suggest that pregnancy is possible and if female participants are premenopausal and of child-bearing age. Subjects will not be able to enroll if they are breastfeeding.

Where it's recruiting

Massachusetts

Boston

Source: ClinicalTrials.gov · NCT05336695 · last updated 2025-10-30