RecruitingInfluenza
Systems Investigation of Vaccine Responses in Aging and Frailty
Eligible age
21+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This study will compare the immune response signatures (including immunologic, transcriptomic and metabolomic) of the two influenza vaccines approved for use in adults age 65 and over (Fluad and Fluzone High-Dose).
Sponsor: Yale University
You may qualify if…
- ✓ Age 21-40 or 65 and older
- ✓ Ability to understand and give informed consent (surrogate consent may apply to nursing home subjects who are decisionally impaired, with verbal assent to be obtained from subject)
- ✓ Plan to be in the New Haven, CT area for the next 4-6 weeks
You may not qualify if…
- ✕ Current use of medication, such as antibiotics in past two weeks. To clarify, patients taking antibiotics for the reason of a current acute infection will not be eligible. Those potential participants receiving antibiotics for prophylaxis purposes will be eligible to participate. The intention is not to create a separate group to drawn conclusions, but not to exclude these participants who are not acutely ill.
- ✕ Evidence of acute infection, identified by self- report of fever or symptoms in past two weeks
- ✕ Treatment for cancer in past three months.
- ✕ Previous adverse reaction to influenza vaccine requiring medical attention, such as allergic response (rash, anaphylaxis) or Guillain-Barré syndrome.
- ✕ Pregnant/possibly pregnant.
- ✕ History of organ, bone marrow or stem cell transplant, liver cirrhosis, kidney disease requiring dialysis, HIV/AIDS, hepatitis C or active hepatitis B
- ✕ Blood donation of 1 pint or more in past 2 months
- ✕ Treatment with clinical trial medication
Where it's recruiting
Connecticut
New Haven
Source: ClinicalTrials.gov · NCT05291676 · last updated 2025-06-12