RecruitingAMCI - Amnestic Mild Cognitive ImpairmentSleep Disturbance

Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone

Eligible age

55+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

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About this study

To investigate the effect of trazodone on sleep, hippocampal-dependent memory and hippocampal excitability. The investigators hypothesize that trazodone will improve total sleep time and proportion of time in Slow Wave Sleep (SWS).

Sponsor: Johns Hopkins University

You may qualify if…

✓ 1. Mild Cognitive Impairment (MCI) as defined by Albert et al.2 including subjective memory complaint and/or objective evidence of memory problems;
✓ 2. Clinical Dementia Rating (CDR) of 0.5 with a Memory Box score of \>=0.5;
✓ 3. Evidence of sleep complaints with Pittsburgh Sleep Quality Index score of \>5 (a well-validated cutoff observed in \>40% of older persons);
✓ 4. Memory performance \> 1.5 Standard Deviation (SD) below age-and education-matched control subjects on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) List Recall;
✓ 5. Visual and auditory acuity adequate for neuropsychological testing;
✓ 6. Good general health with no disease expected to interfere with the study;
✓ 7. Able to have Magnetic Resonance Imaging (MRI) scan;
✓ 8. Availability of knowledgeable informant (KI)

You may not qualify if…

✕ 1. Less than 55 years of age to reduce likelihood of including individuals with frontotemporal dementia or non-dementia MCI;
✕ 2. Too frail or medically unstable to undergo study procedures;
✕ 3. Prior diagnosis of Obstructive Sleep Apnea (OSA) or evidence of moderate-to-severe OSA on baseline Home Sleep Test (HST) as evidenced by an apnea/hypopnea index of \>15;
✕ 4. Dementia;
✕ 5. Cognitive complaints and deficits better explained by other medical/neurologic conditions;
✕ 6. Delirium;
✕ 7. Allergic to trazodone;
✕ 8. Taking sleep medications including trazodone;

Where it's recruiting

Maryland

Baltimore

Source: ClinicalTrials.gov · NCT05282550 · last updated 2026-06-17