GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have \~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.
Sponsor: University of Alabama at Birmingham
You may qualify if…
- ✓ Adults: Age more than or equal to 18; an equal number of Males and Females
- ✓ Consent to the collection of genetic material
- ✓ Willing to adhere to the study protocol
You may not qualify if…
- ✕ Age \<18, at screening.
- ✕ BMI \>45 kg/m2.
- ✕ Blood pressure more than 140/90 mmHg.
- ✕ Participants who are taking more than 2 hypertension medications.
- ✕ History of diabetes or fasting plasma glucose \>126 mg/dl or HbA1C\>=6.5% or prior treatment with antidiabetic medication.
- ✕ Have any past or present history of cardiovascular diseases (stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia)
- ✕ Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence);
- ✕ Estimated GFR \< 60 ml/min/1.73 m2; albumin creatinine ratio ≥30 mg/g
Where it's recruiting
Birmingham
Source: ClinicalTrials.gov · NCT05216042 · last updated 2026-04-09