Sit Less, Interact and Move More (SLIMM) 2 Study
Eligible age
20+ yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
* Prolonged sitting (sedentary behavior) is a risk factor for decreased kidney function, obesity, diabetes and mortality. Prolonged sitting is associated with decreased kidney function and increased risk of diabetes, heart disease and death. * In a previous pilot study funded by NIH, it was shown that a Sit Less, Interact and Move More (SLIMM) intervention targeting sedentary behavior in people with kidney disease was able to decrease prolonged sitting but that effect was not sustained. * Therefore, the researchers are currently conducting a follow-up study named Sit Less, Interact and Move More (SLIMM) 2. * This NIH funded study is conducted at the University of Utah and Stanford University. * The purpose of this study is to see if guided resistance training (to improve muscle strength) and semaglutide (FDA approved diabetes and weight loss medication that might also improve physical function) can boost adherence to the SLIMM Intervention and reduce sedentary behavior.
Sponsor: Srinvasan Beddhu
You may qualify if…
- ✓ Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Glomerular Filtration Rate (eGFR) 20 to \<60 mL/min/1.73m\^2
- ✓ Able to perform resistance training
- ✓ Access to compatible "smartphone" or device (i.e., Android, Kindle or Apple with internet connectivity or mobile network), desktop or laptop
You may not qualify if…
- ✕ Type 1 Diabetes
- ✕ History of gastroparesis or paralytic ileus
- ✕ At baseline, if sedentary time is 25 min/hr or less, measured by accelerometer
- ✕ Potential contraindications to semaglutide such as a history of pancreatitis, and a family or personal history of multiple endocrine neoplasia type 2 or familial medullary thyroid carcinoma.
- ✕ Previous bariatric surgery
- ✕ Medical condition likely to limit survival to less than 1 year
- ✕ Anticipated start of dialysis or kidney transplantation within 6 months
- ✕ Any factors judged by the investigator or study team to likely limit adherence to interventions
Where it's recruiting
Stanford
Salt Lake City
Source: ClinicalTrials.gov · NCT05173714 · last updated 2026-07-27