Vaccine Responses in Patients With B Cell Malignancies
Eligible age
18–90 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Background: People with B cell malignancies (blood cancers) often cannot mount a full immune response to infections or certain vaccines. Bruton tyrosine kinase inhibitors (BTKis), which are used to treat blood cancers, may also negatively affect a person s response to certain vaccines. Researchers want to learn more about vaccine responses in people with certain types of blood cancers. The findings may help develop better vaccine strategies for people with these cancers. Objective: To learn how well vaccines work in people who have certain types of blood cancers. Eligibility: Adults aged 18 years or older who have chronic lymphocytic leukemia (CLL), Waldenstrom macroglobulinemia, or certain non-Hodgkin lymphomas. Design: Participants will get one or more vaccines for illnesses such as COVID-19, hepatitis B, and shingles. They can choose which vaccines they receive. They will give a blood sample before they get each vaccine. Some vaccines require a second dose 3-6 weeks later. Participants may give an optional blood sample with the second vaccine dose. About 4 weeks after they finish each vaccine series, they will give another blood sample. They will have 2-3 study visits per vaccine. Participants may receive a booster dose for some vaccines. The booster dose is optional. They will give another blood sample with the booster dose. Participants will have pregnancy tests, if needed. Participants with CLL who receive BTKis may be asked to pause treatment for up to 7 weeks. Participants may give follow-up blood samples up to 2 times a year for 5 years. These blood samples are optional. Participation will last for up to 5 years after each vaccine series is received.
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
You may not qualify if…
- ✕ 1. Female patients who are currently pregnant
- ✕ 2. History of severe allergic reaction to vaccines
- ✕ 3. Concomitant inherited immunodeficiency
- ✕ 4. Any life-threatening illness, medical condition, or organ system dysfunction that, in the investigator s opinion, could compromise the subject s safety or put the study outcomes at undue risk.
- ✕ 5. Receive cytotoxic chemotherapy within 2 weeks prior to vaccination
- ✕ 6. Receive intravenous immunoglobulin (IVIG) within 2 months prior to vaccination
- ✕ 7. Receive anti-CD20 and/or anti-CD19 monoclonal antibody therapy within 6 months prior to vaccination
- ✕ 8. Receive cellular therapy (e.g. CAR-T cells) within 12 months prior to vaccination
Where it's recruiting
Bethesda
Source: ClinicalTrials.gov · NCT05170399 · last updated 2026-02-05