OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more severe than outpatient settings. Obstructive sleep apnea (OSA) is highly comorbid with both disorders and untreated OSA is associated with worse functional impairment across multiple domains, worse quality of life, worse PTSD, higher suicidal ideation, and higher substance use and relapse rates. Treating OSA with evidence-based positive airway pressure (PAP) in Veterans with SUD/PTSD on a residential unit is a logical way to maximize treatment adherence and treatment outcomes. This study compares OSA treatment while on a SUD/PTSD residential unit to a waitlist control group. The investigators hypothesize that treating OSA on the residential unit, compared to the waitlist control, will have better functional, SUD, and PTSD outcomes.
Sponsor: VA Office of Research and Development
You may qualify if…
- ✓ a Veteran of the U.S. military or Reserve/National Guard member
- ✓ at least 18 years of age
- ✓ have an AHI 5 per hour
- ✓ experienced trauma that occurred in childhood or adulthood; at least one month post-trauma
- ✓ have current DSM-5 diagnoses of SUD via SCID-SUD module with a minimum 20 days of substance use in the last 90 days (Timeline Follow-back)
- ✓ Full PTSD diagnosis via clinician administered PTSD scale
- ✓ are literate in English
- ✓ are on the PTSD track of the SARRTP unit
You may not qualify if…
- ✕ have central sleep apnea (AHI \>=5 and \> 50% central apneas)
- ✕ arrives on the SARRTP unit already using a PAP device (Veteran's previously diagnosed with OSA, but not using PAP therapy will be eligible)
- ✕ the SARRTP medical staff advises against the study based on medical history and physical examination; d) history of severe cognitive impairment (via MOCA \< 26)
- ✕ history of psychosis or mania independent of substance use will be excluded because the presence of these disorders can impede therapy progress
Where it's recruiting
San Diego
Source: ClinicalTrials.gov · NCT05156112 · last updated 2025-11-03