Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
Eligible age
18–75 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
Yes
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About this study
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.
Sponsor: CHU de Reims
You may qualify if…
- ✓ 1. OSAS patients
- ✓ severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h
- ✓ without CPAP treatment
- ✓ 2. Non-OSAS patients
- ✓ absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11)
- ✓ Non-inclusion criteria :
- ✓ \< 18 years old
- ✓ \>75 years old
You may not qualify if…
- ✕ pregnant woman according to the positive beta-hCG test result
- ✕ left-handed following the laterality questionnaire
- ✕ MINI results showing:
- ✕ a current mood episode
- ✕ a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)
- ✕ an eating disorder
- ✕ a diagnosis of bipolar disorder, current or past schizophrenia
Source: ClinicalTrials.gov · NCT05147649 · last updated 2025-12-02